Showing 12 results for Researcher: Leighton Coates
August 4, 2022
2 MIN READ
The COVID-19 pandemic continues to disrupt everyday life, with constantly emerging SARS-CoV-2 variants threatening effectiveness of current vaccines. Small-molecule antivirals can provide an important therapeutic treatment option.
June 10, 2021
9 MIN READ
An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.
June 10, 2021
4 MIN READ
Scientists at Oak Ridge National Laboratory have uncovered how the SARS-CoV-2 virus evades the human immune system by studying the interaction between a viral protein (PLpro) and a key immune protein (ISG15). These insights could guide the development of therapeutic drugs to block this interaction, enhancing the body’s ability to combat the virus.
March 23, 2021
5 MIN READ
Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.
November 16, 2020
5 MIN READ
Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.
October 27, 2020
4 MIN READ
To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.
June 25, 2020
5 MIN READ
A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.
March 1, 2018
1 MIN READ
New insights into certain catalytic enzymes formed by bacteria to break down antibiotics may lead to the design of drugs better equipped to combat resistant bacteria. Scientists at Oak Ridge National Laboratory used neutron crystallography at the lab’s Spallation Neutron Source to st...
November 13, 2017
4 MIN READ
A new study sheds light on a unique enzyme that could provide an eco-friendly treatment for chlorite-contaminated water supplies and improve water quality worldwide. An international team of researchers led by Christian Obinger from the University of Vienna used neutron analys...
November 6, 2017
5 MIN READ
The discovery of penicillin almost 90 years ago ushered in the age of modern antibiotics, but the growth of antibiotic resistance means bacterial infections like pneumonia and tuberculosis are becoming more difficult to treat.
October 7, 2015
5 MIN READ
Plants and other biomass can be converted into a variety of renewable high-value products including carbon fibers, plastics, and liquid fuels such as ethanol and biodiesel that are beneficial for reducing petroleum use and vehicle emissions. Breaking down plants in order to release...