Oct, 2025
Journal
Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency
Background Epigenetic modifications, nucleosome occupancy, and three-dimensional chromatin architecture collectively create a multi-layered, highly interactive regulatory system for controlling genomic functionality. Dysregulation of epigenetic processes leads to a plethora of abnormalities including disease states. Therapies focused on epigenetic modulation can alter gene…