- By:
- Allen, Christian H; San soucie, Miles; Benson, Ryan; Glezakou-Elbert, Ourania-Maria ; Jimenez, Ralph; Morrell-Falvey, Jennifer L; Ma, Yingzhong
- Page Number:
- 59-67
- Volume:
- 13872
- Book Title:
- Quantum Effects and Measurement Techniques in Biology and Biophotonics III
- Publication Date:
- May 20, 2026
- Publisher Location:
- SPIE, Georgia, United States of America
- Conference Name:
- Photonics West 2026 BiOS: Quantum Effects and Measurement Techniques in Biology and Biophotonics
- Conference Location:
- San Francisco, California, United States of America
- Conference Sponsor:
- SPIE
- View DOI Listing:
- https://doi.org/10.1117/12.3080097
Abstract
The feasibility of nonlinear optical (NLO) imaging and spectroscopy using low intensity quantum states of light including entangled photon and squeezed light sources, such as those driven by two-photon absorption (TPA), has been a topic of ongoing debate. An unambiguous identification of the appreciable quantum advantage in such quantum light applications could enable NLO imaging of biological samples without photodegradation and phototoxicity. Recently, we have constructed a two-mode squeezed light source based on four-wave mixing in 85Rb vapor, which is capable of 7.9 dB of intensity-difference squeezing (IDS), corresponding to 8.7 dB upon electronic noise correction. In this talk, we discuss the stability of our system, including implementation details on achieving and maintaining 8.7 dB of IDS for several hours, and ensuring the two spatially multimode beams are properly overlapped in a sample with minimal optical loss.
