- By:
- Garza Elizondo, Andrea M; Del Valle Kessra, Ilenne D; Teixeira Prates, Erica ; Komp, Evan; Kammerdiener, Elise K; Ashok, Nandhini ; Jacobson, Daniel A; Webb, Erin G; Bomble, Yannick; Alexander, William G; Tannous, Joanna ; Tsai, Chung-Jui; Parrott, Wayne; Yang, Xiaohan ; Urbanowicz, Breeanna; Bartley, Laura; Maranas, Costas; Tuskan, Gerald A; Guss, Adam M; Eckert, Carrie A
- Journal Name:
- Biotechnology Advances
- Page Number:
- 108775
- Volume:
- 87
- Publication Date:
- December 17, 2025
- View DOI Listing:
- https://doi.org/10.1016/j.biotechadv.2025.108775
Abstract
The field of synthetic biology is essential to the continued development of a bio-based economy, creating mechanisms to supply carbon needed in the economy by both converting existing end-of-life wastes as well as by creating novel, purpose-grown and sustainable feedstocks. Here, we first discuss the near- and long-term resources available for use as feedstocks for bioconversion as well as the output molecules needed for building the foundation of an expanded bio-based economy. We then outline the organisms and phenotypic traits that are needed for the performance-advantaged chassis organisms of the future. Furthermore, we detail the advances, challenges, and opportunities in both microbial and plant synthetic biology relevant to expanding the bio-based economy. Finally, we explore technologies that have and will further enable advances in synthetic biology and the greater bio-based economy.
