- By:
- Bocharova, Vera ; Drufva, Erin E; Cahill, John F; Popov, Ivan ; Dishner, Isaiah T; Zhou, Muchu ; Jung, Gang Seob ; Ullman, Andrew M; Carper, Dana L; Damron, Joshua T; Keum, Jong K; Gainaru, Catalin P; Chen, Szu Hua ; Foster, Jeffrey C; Michener, Joshua K
- Journal Name:
- Polymer Chemistry
- Page Number:
- 1858-1868
- Volume:
- 16
- Publication Date:
- April 17, 2025
- View DOI Listing:
- https://doi.org/10.1039/D5PY00023H
Abstract
The enzymatic hydrolysis of polyamides offers a promising approach to reduce the environmental impact of chemical recycling by enabling lower reaction temperatures, eliminating toxic organic solvents, and enhancing product selectivity. Achieving this goal will require increasing the low overall yield of enzymatic hydrolysis. In this work, we studied the mechanism of hydrolysis of commercial Nylon-6,6 polymer with a thermostable Nylon hydrolyzing enzyme and identified the substrate characteristics that influence the efficiency and deconstruction product yield. These results will guide the development of effective substrate pre-treatment methods to improve the yield of valuable oligoamide building blocks via enzymatic hydrolysis.
