- By:
- Yinda, Claude; Vlot, Hendrika C; Teixeira Prates, Erica ; Shah, Manesh B; Pavicic Venegas, Mirko Vierislav ; Carr, William H; Jacobson, Daniel A; Anzick, Sarah; Wang, Jianning; Halpin, Kim; Borremans, Benny; Lunn, Tamika; Eden, John-Sebastian; Barbian, Kent; Greene, Benjamin; Meade-White, Kimberly; Bushmaker, Trenton; Falvo, Caylee; Crowley, Daniel; Jones-Slobodian, Devin; Martens, Craig; Health Group, Bat One; Plowright, Raina; Peel, Alison; Munster, Vincent
- Journal Name:
- Nature Microbiology
- Page Number:
- 851-866
- Volume:
- 11
- Publication Date:
- April 9, 2026
- View DOI Listing:
- https://doi.org/10.1038/s41564-025-02254-7
Abstract
Hendra virus (HeV) was discovered in 1994 in Australia. Limited genomic data have hindered comprehensive understanding of HeV’s evolutionary dynamics. Here we recovered 48 HeV genomes from bats and 9 from horses from Australia between 2016 and 2020, revealing four distinct clades. Each clade was distributed over a large spatial area with multiple clades co-circulating within a single bat roost on the same day and over consecutive years. The diversity and temporal stability of co-circulating clades suggest that viral dynamics are driven by episodic shedding of existing lineages maintained at the population level, rather than immune-driven strain-replacement dynamics. HeV isolates of different clades displayed variation in phenotypic properties but minimal antigenic differences. We provide an overview of evolutionary dynamics, phenotypic properties and assessment of countermeasures for HeV, and provide insights into the processes that maintain virus diversity in bats and influence the potential for viral emergence.
